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KMID : 0380020150300060326
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Korean Journal of Biotechnology and Bioengineering
2015 Volume.30 No. 6 p.326 ~ p.331
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Anti-inflammatory Effect of Water Extract from Tuna Heart on Lipopolysaccharide-induced Inflammatory Responses in RAW 264.7 Cells
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Kim Min-Ji
Bae Nan-Young
Kim Koth-Bong-Woo-Ri
Park Ji-Hye
Park Sun-Hee
Cho Young-Je
Ahn Dong-Hyun
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Abstract
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The anti-inflammatory effect of tuna heart water extract (THWE) was investigated using lipopolysaccharide-induced inflammatory response in this study. Anti-inflammatory effect was detected by the cell proliferation and the production levels of nitric oxide, pro-inflammatory cytokines such as interleukin-6 (IL-6), IL-1β, and tumor necrosis factoralpha. As a result, there were no cytotoxic effects on proliferation of macrophages treated with THWE compared to the control. The production of pro-inflammatory cytokines was remarkably suppressed compared with that of the LPS only group. These results suggest that THWE exerts the anti-inflammatory property by inhibiting production of inflammatory factors and may be a potential material for anti-inflammatory therapy.
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KEYWORD
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Anti-inflammation, Pro-inflammatory cytokine, Nitric oxide, Tuna heart
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